聯絡方式
電話：04-22052121 分機：7921
地址：台中市北區學士路91號
E-mail：tms@mail.cmu.edu.tw


近期發表成果
  1. Chang WC, Wang HC, Cheng WC, Yang JC, Chung WM, Ho YP, Chen L, Hung YC, Ma WL*: LDLR-mediated lipidome-transcriptome reprogramming in cisplatin insensitivity. Endocr Relat Cancer, 2019. PubMed
  2. Liu SH, Shen PC, Chen CY, Hsu AN, Cho YC, Lai YL, Chen FH, Li CY, Wang SC, Chen M, Chung IF, Cheng WC*. DriverDBv3: a multi-omics database for cancer driver gene research. Nucleic Acids Res, 2019. PubMed
  3. Yang JC, Chang N, Wu DC, Cheng WC, Chung WM, Chang WC, Lei FJ, Liu CJ, Wu IC, Lai HC, Ma WL*: Preclinical evaluation of exemestane as a novel chemotherapy for gastric cancer. J Cell Mol Med, 2019. PubMed
  4. Yu CC, Chen LC, Lin VC, Huang CY, Cheng WC, Hsieh AR, Chang TY, Lu TL, Lee CH, Huang SP, Bao BY: Effect of genetic variants in cell adhesion pathways on the biochemical recurrence in prostate cancer patients with radical prostatectomy. Cancer Med, 2019. PubMed
  5. Hung YL, Wang SC, Suzuki K, Fang SH, Chen CS, Cheng WC, Su CC, Yeh HC, Tu HP, Liu PL, Huang MY, Li CY: Bavachin attenuates LPS-induced inflammatory response and inhibits the activation of NLRP3 inflammasome in macrophages. Phytomedicine, 2019. PubMed
  6. Cheng WC, Liao TT, Lin CC, Yuan LE, Lan HY, Lin HH, Teng HW, Chang HC, Lin CH, Yang CY, Huang SC, Jiang JK, Yang SH, Yang MH*, Hwang WL*: RAB27B-activated secretion of stem-like tumor exosomes delivers the biomarker microRNA-146a-5p, which promotes tumorigenesis and associates with an immunosuppressive tumor microenvironment in colorectal cancer Int J Cancer, 2019. PubMed
  7. Liu LC, Wang YL, Lin PL, Zhang X, Cheng WC, Liu SH, Chen CJ, Hung Y, Jan CI, Chang LC, Qi X, Hsieh-Wilson LC, Wang SC*: Long non-coding RNA HOTAIR promotes invasion of breast cancer cells through chondroitin sulfotransferase CHST15 Int J Cancer, 2019. PubMed
  8. Su CC, Hsieh KL, Liu PL, Yeh HC, Huang SP, Fang SH, Cheng WC, Huang KH, Chiu FY, Lin IL, Huang MY, Li CY*: AICAR Induces Apoptosis and Inhibits Migration and Invasion in Prostate Cancer Cells Through an AMPK/mTOR-Dependent Pathway Int J Mol Sci, 2019. PubMed
  9. Kao SH, Cheng WC, Wang YT, Wu HT, Yeh HY, Chen YJ, Tsai MH, Wu KJ*: Regulation of miRNA biogenesis and histone modification by K63-polyubiquitinated DDX17 controls cancer stem-like features Cancer Res, 2019. PubMed
  10. Han Y, Yang J, Qian X, Cheng WC, Liu SH, Hua X, Zhou L, Yang Y, Wu Q, Liu P, Lu Y*: DriverML: a machine learning algorithm for identifying driver genes in cancer sequencing studies Nucleic Acids Res, 2019. PubMed
  11. Hsu RH, Hwu WL, Chen M, Chung IF, Peng SS, Chen CY, Cheng WC, Chien YH, Lee NC*: Next-generation sequencing identifies TRPV4-related skeletal dysplasia in a boy with progressive bowlegs Pediatr Neonatol, 2019. PubMed
  12. Hwang WL, Lan HY, Cheng WC, Huang SC, Yang MH*: Tumor stem-like cell-derived exosomal RNAs prime neutrophils for facilitating tumorigenesis of colon cancer J Hematol Oncol, 2019. PubMed
  13. Huang CY, Hsueh YM, Chen LC, Cheng WC, Yu CC, Chen WJ, Lu TL, Lan KJ, Lee CH, Huang SP, Bao BY*.: Clinical significance of glutamate metabotropic receptors in renal cell carcinoma risk and survival Cancer Med., 2018. PubMed
  14. Huang MY, Tu CE, Wang SC, Hung YL, Su CC, Fang SH, Chen CS, Liu PL, Cheng WC, Huang YW, Li CY*.: Corylin inhibits LPS-induced inflammatory response and attenuates the activation of NLRP3 inflammasome in microglia BMC Complement Altern Med., 2018. PubMed
  15. Gong L, Wong CH, Cheng WC, Tjong H, Menghi F, Ngan CY, Liu ET, Wei CL.: Picky comprehensively detects high-resolution structural variants in nanopore long reads Nat Methods, 2018. PubMed
  16. Shih JC, Ma GC, Cheng WC, Chen CY, Wu WJ, Chen M: SMAD2 as a risk locus for human left atrial isomerism detected by mother-fetus-pair exome sequencing and image studies including fetal ultrasound Ultrasound Obstet Gynecol, 2018. PubMed
  17. Kao TL, Kuan YP, Cheng WC, Chang WC, Jeng LB, Yeh S, Ma WL: Estrogen receptors orchestrate cell growth and differentiation to facilitate liver regeneration Theranostics, 2018. PubMed
  18. Chang WC, Cheng WC, Cheng BH, Chen L, Ju LJ, Ou YJ, Jeng LB, Yang MD, Hung YC, Ma WL: Mitochondrial Acetyl-CoA Synthetase 3 is Biosignature of Gastric Cancer Progression Cancer Med., 2018. PubMed
  19. Lin KH, Huang MY, Cheng WC, Wang SC, Fang SH, Tu HP, Su CC, Hung YL, Liu PL, Chen CS, Wang YT, Li CY: RNA-seq transcriptome analysis of breast cancer cell lines under shikonin treatment Sci Rep., 2018. PubMed
  20. Fan CC, Cheng WC, Huang YC, Sher YP, Liou NJ, Chien YC, Lin PS, Lin PS, Chen CH, Chang WC: EFHD2 promotes epithelial-to-mesenchymal transition and correlates with postsurgical recurrence of stage I lung adenocarcinoma Sci Rep., 2017. PubMed
  21. Wu MZ, Cheng WC, Chen SF, Nieh S, Connor CO, Liu CL, Tsai WW, Wu CJ, Martin L, Lin YS, Wu KJ, Lu LF, and Belmonte JC: miR25/93 mediates hypoxia-induced immunosuppression by repressing cGAS Nat Cell Biol, 2017. PubMed
  22. Chen L, Bao BY, Chang WC, Ho JY, Cheng BH, Wang CL, Tang Q, Cheng WC, Chang HW, Hung YC, Ma WL: Short androgen receptor poly-glutamine-promoted endometrial cancer is associated with benzo[a]pyrene-mediated aryl hydrocarbon receptor activation J Cell Mol Med , 2017. PubMed
  23. Chiu KL, Lin YS, Kuo TT, Lo CC, Huang YK, Chang HF, Chuang EY, Lin CC, Cheng WC, Liu YN, Lai LC, and Sher YP: ADAM9 Enhances CDCP1 by Inhibiting miR-1 through EGFR Signaling Activation in Lung Cancer Metastasis Oncotarget , 2017. PubMed
  24. Hung YL, Fang SH, Wang SC, Cheng WC, Su CC, Chen CS, Huang MY, Hua KF, Shen KH, Wang YT, Suzuki K*, Li CY: Corylin protects LPS-induced sepsis and attenuates LPS-induced inflammatory response Sci Rep. , 2017. PubMed
  25. Chung IF, Chang SH, Chen CY, Liu SH, Li CY, Chan CH, Shih CC, Cheng WC: YM500v3: a database for small RNA sequencing in human cancer research. Nucleic Acids Res, , Jun 2017. PubMed
  26. Wu HT, Kuo YC, Hung JJ, Huang CH, Chen WY, Chou TY, Chen Y, Chen YJ, Chen YJ, Cheng WC,Teng SC, Wu KJ.: K63-polyubiquitinated HAUSP deubiquitinates HIF-1α and dictates H3K56 acetylation promoting hypoxia-induced tumour progression. Nat Commun, , 2016 Dec. PubMed
  27. Chang WC, Huang SF, Lee YM, Lai HC, Cheng BH, Cheng WC, Ho YP, Jeng LB, Ma WL.: Cholesterol import and steroidogenesis are biosignatures for gastric cancer patient survival. Oncotarget, , 2016 Nov. PubMed
  28. Lai HC, Yeh CC, Jeng LB, Huang SF, Liao PY, Lei FJ, Cheng WC, Hsu CL, Cai X, Chang C, Ma WL: Androgen receptor mitigates postoperative disease progression of hepatocellular carcinoma by suppressing CD90+ populations and cell migration and by promoting anoikis in circulating tumor cells. Oncotarget 2016, Jun 20. PubMed
  29. Hsu KW, Fang WL, Huang KH, Huang TT, Lee HC, Hsieh RH, Chi CW, Yeh TS: Notch1 pathway-mediated microRNA-151-5p promotes gastric cancer progression. Oncotarget 2016, 7(25):38036-51. PubMed
  30. Huang KY, Kao SH, Wang WL, Chen CY, Hsiao TH, Salunke SB, Chen JJ, Su KY, Yang SC, Hong TM, Chen CS, Yang PC: Small Molecule T315 Promotes Casitas B-Lineage Lymphoma-Dependent Degradation of Epidermal Growth Factor Receptor via Y1045 Autophosphorylation. American Journal of Respiratory and Critical Care Medicine 2016, 193(7):753-66. PubMed
  31. Kao SH, Wu KJ, Lee WH: Hypoxia, Epithelial-Mesenchymal Transition, and TET-Mediated Epigenetic Changes. Journal of Clinical Medicine 2016, 5(2), 24. PubMed
  32. Wang LK, Pan SH, Chang YL, Hung PF, Kao SH, Wang WL, Lin CW, Yang SC, Liang CH, Wu CT, Hsiao TH, Hong TM, Yang PC: MDA-9/Syntenin-Slug transcriptional complex promote epithelial-mesenchymal transition and invasion/metastasis in lung adenocarcinoma. Oncotarget 2016, 5;7(1):386-401. PubMed
  33. Chen HF, Wu KJ: Endothelial Transdifferentiation of Tumor Cells Triggered by the Twist1-Jagged1-KLF4 Axis: Relationship between Cancer Stemness and Angiogenesis. Stem Cells International 2016:6439864. PubMed
  34. Tseng SJ, Liao ZX, Kao SH, Zeng YF, Huang KY, Li HJ, Yang CL, Deng YF, Huang CF, Yang SC, Yang PC, Kempson IM: Highly specific in vivo gene delivery for p53-mediated apoptosis and genetic photodynamic therapies of tumour. Nature communications 2015, 5;6:6456. PubMed
  35. Chung IF, Chen CY, Su SC , Li CY, Wu KJ , Wang HW, Cheng WC : DriverDBv2: a database for human cancer driver gene research. Nucleic Acids Research 2015 Dec 3. pii: gkv1314. PubMed
  36. Yan FQ, Wang JQ, Tsai YP, Wu KJ: HSP60 overexpression increases the protein levels of the p110α subunit of  phosphoinositide 3-kinase and c-Myc. Clinical and Experimental Pharmacology and Physiology 2015, 42(10):1092-1097. PubMed
  37. Tseng JC, Chen HF, Wu KJ: A twist tale of cancer metastasis and tumor angiogenesis. THistology and Histopathology 2015, 30(11):1283-1294. PubMed
  38. Kuo YC, Wu HT, Hung JJ, Chou TY, Teng SC, Wu KJ: Nijmegen breakage syndrome protein 1 (NBS1) modulates hypoxia inducible factor-1α (HIF-1α) stability and promotes in vitro migration and invasion under ionizing radiation. The International Journal of Biochemistry & Cell Biology 2015, 64(0):229-238. PubMed
  39. Wang JQ, Wu KJ: Epigenetic Regulation of Epithelial-Mesenchymal Transition by Hypoxia in Cancer: Targets and Therapy. Current Pharmaceutical Design 2015, 21(10):1272-1278. PubMed
  40. Chang LC, Yu YL, Liu CY, Cheng YY, Chou RH, Hsieh MT, Lin HY, Hung HY, Huang LJ, Wu YC, Kuo SC: The newly synthesized 2-arylnaphthyridin-4-one, CSC-3436, induces apoptosis of non-small cell lung cancer cells by inhibiting tubulin dynamics and activating CDK1. Cancer Chemother Pharmacol 2015, 75(6):1303-1315. PubMed
  41. Hsieh TC, Hsieh CY, Yang TY, Chen TT, Lin CY, Lin CC, Hua CH, Chiu CF, Yeh SP, Sher YP: [18F]-Fluorodeoxyglucose Positron Emission Tomography Standardized Uptake Value as a Predictor of Adjuvant Chemotherapy Benefits in Patients With Nasopharyngeal Carcinoma. The Oncologist 2015, 20(5):539-545. PubMed
  42. Wang HW, Sun HJ, Chang TY, Lo H-H, Cheng WC, Tseng GC, Lin CT, Chang SJ, Pal NR, Chung IF: Discovering monotonic stemness marker genes from time-series stem cell microarray data. BMC Genomics 2015, 16(Suppl 2):S2-S2. PubMed
  43. Cheng WC, Chung IF, Tsai CF, Huang TS, Chen CY, Wang SC, Chang TY, Sun HJ, Chao JY, Cheng CC7, Wu CW, Wang HW: YM500v2: a small RNA sequencing (smRNA-seq) database for human cancer miRNome research. Nucleic Acids Research 2015, 43(Database issue):D862-D867. PubMed
  44. Chen HF, Huang CH, Liu CJ, Hung JJ, Hsu CC, Teng SC, Wu KJ: Twist1 induces endothelial differentiation of tumour cells through the Jagged1-KLF4 axis. Nat Commun 2014, 5. PubMed
  45. Chang LC, Lin HY, Tsai MT, Chou RH, Lee FY, Teng CM, Hsieh MT, Hung HY, Huang LJ, Yu YL, Kuo SC: YC-1 inhibits proliferation of breast cancer cells by down-regulating EZH2 expression via activation of c-Cbl and ERK. British Journal of Pharmacology 2014, 171(17):4010-4025. PubMed
  46. Tsai SC, Tsai MH, Chiu CF, Lu CC, Kuo SC, Chang NW, Yang JS: AMPK-dependent signaling modulates the suppression of invasion and migration by fenofibrate in CAL 27 oral cancer cells through NF-κB pathway. Environmental Toxicology 171(17):4010-4025. PubMed
  47. Huang HL, Kung PT, Chiu CF, Wang YH, Tsai WC: Factors Associated with Lung Cancer Patients Refusing Treatment and Their Survival: A National Cohort Study under a Universal Health Insurance in Taiwan. PLoS ONE 2014, 9(7):e101731. PubMed
  48. Bai LY, Lin WY, Chiu CF, Weng JR: Anti-tumor activities of triterpenes from Syzygium kusukusense. Nat Prod Commun 2014, 9(11):1557-1558. PubMed
  49. Penumutchu SR, Chou RH, Yu C: Interaction between S100P and the anti-allergy drug cromolyn. Biochemical and Biophysical Research Communications 2014, 454(3):404-409. PubMed
  50. Tsai YP, Chen HF, Chen SY, Cheng WC, Wang HW, Shen ZJ, Song C, Teng SC, He C, Wu KJ: TET1 regulates hypoxia-induced epithelial-mesenchymal transition by acting as a co-activator. Genome Biology 2014, 15(12):513. PubMed