近期發表成果
- Chang WC, Wang HC, Cheng WC, Yang JC, Chung WM, Ho YP, Chen L, Hung YC, Ma WL*:
LDLR-mediated lipidome-transcriptome reprogramming in cisplatin insensitivity.
Endocr Relat Cancer, 2019.
PubMed
- Liu SH, Shen PC, Chen CY, Hsu AN, Cho YC, Lai YL, Chen FH, Li CY, Wang SC, Chen M, Chung IF, Cheng WC*.
DriverDBv3: a multi-omics database for cancer driver gene research.
Nucleic Acids Res, 2019.
PubMed
- Yang JC, Chang N, Wu DC, Cheng WC, Chung WM, Chang WC, Lei FJ, Liu CJ, Wu IC, Lai HC, Ma WL*:
Preclinical evaluation of exemestane as a novel chemotherapy for gastric cancer.
J Cell Mol Med, 2019.
PubMed
- Yu CC, Chen LC, Lin VC, Huang CY, Cheng WC, Hsieh AR, Chang TY, Lu TL, Lee CH, Huang SP, Bao BY:
Effect of genetic variants in cell adhesion pathways on the biochemical recurrence in prostate cancer patients with radical prostatectomy.
Cancer Med, 2019.
PubMed
- Hung YL, Wang SC, Suzuki K, Fang SH, Chen CS, Cheng WC, Su CC, Yeh HC, Tu HP, Liu PL, Huang MY, Li CY:
Bavachin attenuates LPS-induced inflammatory response and inhibits the activation of NLRP3 inflammasome in macrophages.
Phytomedicine, 2019.
PubMed
- Cheng WC, Liao TT, Lin CC, Yuan LE, Lan HY, Lin HH, Teng HW, Chang HC, Lin CH, Yang CY, Huang SC, Jiang JK, Yang SH, Yang MH*, Hwang WL*:
RAB27B-activated secretion of stem-like tumor exosomes delivers the biomarker microRNA-146a-5p, which promotes tumorigenesis and associates with an immunosuppressive tumor microenvironment in colorectal cancer
Int J Cancer, 2019.
PubMed
- Liu LC, Wang YL, Lin PL, Zhang X, Cheng WC, Liu SH, Chen CJ, Hung Y, Jan CI, Chang LC, Qi X, Hsieh-Wilson LC, Wang SC*:
Long non-coding RNA HOTAIR promotes invasion of breast cancer cells through chondroitin sulfotransferase CHST15
Int J Cancer, 2019.
PubMed
- Su CC, Hsieh KL, Liu PL, Yeh HC, Huang SP, Fang SH, Cheng WC, Huang KH, Chiu FY, Lin IL, Huang MY, Li CY*:
AICAR Induces Apoptosis and Inhibits Migration and Invasion in Prostate Cancer Cells Through an AMPK/mTOR-Dependent Pathway
Int J Mol Sci, 2019.
PubMed
- Kao SH, Cheng WC, Wang YT, Wu HT, Yeh HY, Chen YJ, Tsai MH, Wu KJ*:
Regulation of miRNA biogenesis and histone modification by K63-polyubiquitinated DDX17 controls cancer stem-like features
Cancer Res, 2019.
PubMed
- Han Y, Yang J, Qian X, Cheng WC, Liu SH, Hua X, Zhou L, Yang Y, Wu Q, Liu P, Lu Y*:
DriverML: a machine learning algorithm for identifying driver genes in cancer sequencing studies
Nucleic Acids Res, 2019.
PubMed
- Hsu RH, Hwu WL, Chen M, Chung IF, Peng SS, Chen CY, Cheng WC, Chien YH, Lee NC*:
Next-generation sequencing identifies TRPV4-related skeletal dysplasia in a boy with progressive bowlegs
Pediatr Neonatol, 2019.
PubMed
- Hwang WL, Lan HY, Cheng WC, Huang SC, Yang MH*:
Tumor stem-like cell-derived exosomal RNAs prime neutrophils for facilitating tumorigenesis of colon cancer
J Hematol Oncol, 2019.
PubMed
- Huang CY, Hsueh YM, Chen LC, Cheng WC, Yu CC, Chen WJ, Lu TL, Lan KJ, Lee CH, Huang SP, Bao BY*.:
Clinical significance of glutamate metabotropic receptors in renal cell carcinoma risk and survival
Cancer Med., 2018.
PubMed
- Huang MY, Tu CE, Wang SC, Hung YL, Su CC, Fang SH, Chen CS, Liu PL, Cheng WC, Huang YW, Li CY*.:
Corylin inhibits LPS-induced inflammatory response and attenuates the activation of NLRP3 inflammasome in microglia
BMC Complement Altern Med., 2018.
PubMed
- Gong L, Wong CH, Cheng WC, Tjong H, Menghi F, Ngan CY, Liu ET, Wei CL.:
Picky comprehensively detects high-resolution structural variants in nanopore long reads
Nat Methods, 2018.
PubMed
- Shih JC, Ma GC, Cheng WC, Chen CY, Wu WJ, Chen M:
SMAD2 as a risk locus for human left atrial isomerism detected by mother-fetus-pair exome sequencing and image studies including fetal ultrasound
Ultrasound Obstet Gynecol, 2018.
PubMed
- Kao TL, Kuan YP, Cheng WC, Chang WC, Jeng LB, Yeh S, Ma WL:
Estrogen receptors orchestrate cell growth and differentiation to facilitate liver regeneration
Theranostics, 2018.
PubMed
- Chang WC, Cheng WC, Cheng BH, Chen L, Ju LJ, Ou YJ, Jeng LB, Yang MD, Hung YC, Ma WL:
Mitochondrial Acetyl-CoA Synthetase 3 is Biosignature of Gastric Cancer Progression
Cancer Med., 2018.
PubMed
- Lin KH, Huang MY, Cheng WC, Wang SC, Fang SH, Tu HP, Su CC, Hung YL, Liu PL, Chen CS, Wang YT, Li CY:
RNA-seq transcriptome analysis of breast cancer cell lines under shikonin treatment
Sci Rep., 2018.
PubMed
- Fan CC, Cheng WC, Huang YC, Sher YP, Liou NJ, Chien YC, Lin PS, Lin PS, Chen CH, Chang WC:
EFHD2 promotes epithelial-to-mesenchymal transition and correlates with postsurgical recurrence of stage I lung adenocarcinoma
Sci Rep., 2017.
PubMed
- Wu MZ, Cheng WC, Chen SF, Nieh S, Connor CO, Liu CL, Tsai WW, Wu CJ, Martin L, Lin YS, Wu KJ, Lu LF, and Belmonte JC:
miR25/93 mediates hypoxia-induced immunosuppression by repressing cGAS
Nat Cell Biol, 2017.
PubMed
- Chen L, Bao BY, Chang WC, Ho JY, Cheng BH, Wang CL, Tang Q, Cheng WC, Chang HW, Hung YC, Ma WL:
Short androgen receptor poly-glutamine-promoted endometrial cancer is associated with benzo[a]pyrene-mediated aryl hydrocarbon receptor activation
J Cell Mol Med , 2017.
PubMed
- Chiu KL, Lin YS, Kuo TT, Lo CC, Huang YK, Chang HF, Chuang EY, Lin CC, Cheng WC, Liu YN, Lai LC, and Sher YP:
ADAM9 Enhances CDCP1 by Inhibiting miR-1 through EGFR Signaling Activation in Lung Cancer Metastasis
Oncotarget , 2017.
PubMed
- Hung YL, Fang SH, Wang SC, Cheng WC, Su CC, Chen CS, Huang MY, Hua KF, Shen KH, Wang YT, Suzuki K*, Li CY:
Corylin protects LPS-induced sepsis and attenuates LPS-induced inflammatory response
Sci Rep. , 2017.
PubMed
- Chung IF, Chang SH, Chen CY, Liu SH, Li CY, Chan CH, Shih CC, Cheng WC:
YM500v3: a database for small RNA sequencing in human cancer research.
Nucleic Acids Res, , Jun 2017.
PubMed
- Wu HT, Kuo YC, Hung JJ, Huang CH, Chen WY, Chou TY, Chen Y, Chen YJ, Chen YJ, Cheng WC,Teng SC, Wu KJ.:
K63-polyubiquitinated HAUSP deubiquitinates HIF-1α and dictates H3K56 acetylation promoting hypoxia-induced tumour progression.
Nat Commun, , 2016 Dec.
PubMed
- Chang WC, Huang SF, Lee YM, Lai HC, Cheng BH, Cheng WC, Ho YP, Jeng LB, Ma WL.:
Cholesterol import and steroidogenesis are biosignatures for gastric cancer patient survival.
Oncotarget, , 2016 Nov.
PubMed
- Lai HC, Yeh CC, Jeng LB, Huang SF, Liao PY, Lei FJ, Cheng WC, Hsu CL, Cai X, Chang C, Ma WL:
Androgen receptor mitigates postoperative disease progression
of hepatocellular carcinoma by suppressing CD90+ populations and cell
migration and by promoting anoikis in circulating tumor cells.
Oncotarget 2016, Jun 20.
PubMed
- Hsu KW,
Fang WL, Huang KH, Huang TT, Lee HC, Hsieh RH, Chi CW, Yeh TS: Notch1
pathway-mediated microRNA-151-5p promotes gastric cancer progression.
Oncotarget 2016, 7(25):38036-51.
PubMed
- Huang KY, Kao SH,
Wang WL, Chen CY, Hsiao TH, Salunke SB, Chen JJ, Su KY, Yang SC, Hong
TM, Chen CS, Yang PC: Small Molecule T315 Promotes
Casitas B-Lineage Lymphoma-Dependent Degradation of Epidermal Growth
Factor Receptor via Y1045 Autophosphorylation.
American Journal of Respiratory and Critical Care
Medicine 2016, 193(7):753-66.
PubMed
- Kao SH,
Wu KJ, Lee WH: Hypoxia,
Epithelial-Mesenchymal Transition, and TET-Mediated Epigenetic Changes.
Journal of Clinical Medicine
2016, 5(2), 24.
PubMed
- Wang LK, Pan SH, Chang YL, Hung PF, Kao SH, Wang WL, Lin CW,
Yang SC, Liang CH, Wu CT, Hsiao TH, Hong TM, Yang PC: MDA-9/Syntenin-Slug
transcriptional complex promote epithelial-mesenchymal transition and
invasion/metastasis in lung adenocarcinoma. Oncotarget
2016,
5;7(1):386-401.
PubMed
- Chen HF, Wu KJ: Endothelial
Transdifferentiation
of Tumor Cells Triggered by the Twist1-Jagged1-KLF4 Axis: Relationship
between Cancer Stemness and Angiogenesis. Stem
Cells International
2016:6439864.
PubMed
- Tseng SJ, Liao ZX, Kao
SH, Zeng YF, Huang KY, Li HJ, Yang CL, Deng YF, Huang CF,
Yang SC, Yang PC, Kempson IM: Highly specific in vivo
gene delivery for p53-mediated apoptosis and genetic photodynamic
therapies of tumour. Nature communications
2015, 5;6:6456.
PubMed
- Chung IF, Chen CY,
Su SC , Li CY,
Wu KJ , Wang HW,
Cheng WC : DriverDBv2: a database for
human cancer driver gene research. Nucleic
Acids Research
2015 Dec 3. pii: gkv1314.
PubMed
- Yan FQ, Wang JQ, Tsai YP, Wu
KJ: HSP60 overexpression increases the
protein levels of the p110α subunit of phosphoinositide
3-kinase and c-Myc. Clinical and Experimental
Pharmacology and Physiology
2015, 42(10):1092-1097. PubMed
- Tseng JC, Chen HF,
Wu
KJ:
A twist tale of cancer metastasis and tumor
angiogenesis. THistology and
Histopathology 2015,
30(11):1283-1294. PubMed
- Kuo YC, Wu HT, Hung JJ, Chou TY, Teng SC, Wu KJ: Nijmegen
breakage syndrome protein 1 (NBS1) modulates hypoxia inducible
factor-1α (HIF-1α) stability and promotes in vitro migration and
invasion under ionizing radiation. The
International Journal of Biochemistry & Cell Biology
2015, 64(0):229-238. PubMed
- Wang JQ, Wu
KJ: Epigenetic Regulation of
Epithelial-Mesenchymal Transition by Hypoxia in Cancer: Targets and
Therapy. Current Pharmaceutical Design 2015,
21(10):1272-1278. PubMed
- Chang LC, Yu YL,
Liu CY, Cheng YY, Chou RH,
Hsieh MT, Lin HY, Hung HY, Huang LJ, Wu YC, Kuo SC:
The
newly synthesized 2-arylnaphthyridin-4-one, CSC-3436, induces apoptosis
of non-small cell lung cancer cells by inhibiting tubulin dynamics and
activating CDK1. Cancer Chemother Pharmacol 2015,
75(6):1303-1315. PubMed
- Hsieh TC, Hsieh CY, Yang TY, Chen TT, Lin CY, Lin CC, Hua
CH, Chiu CF,
Yeh SP, Sher YP: [18F]-Fluorodeoxyglucose Positron
Emission Tomography Standardized Uptake Value as a Predictor of
Adjuvant Chemotherapy Benefits in Patients With Nasopharyngeal Carcinoma.
The Oncologist 2015, 20(5):539-545.
PubMed
- Wang HW, Sun HJ, Chang TY, Lo H-H, Cheng WC,
Tseng GC, Lin CT, Chang SJ, Pal NR, Chung IF: Discovering
monotonic stemness marker genes from time-series stem cell microarray
data. BMC Genomics 2015, 16(Suppl
2):S2-S2. PubMed
- Cheng WC, Chung IF, Tsai
CF, Huang TS, Chen CY, Wang SC, Chang TY, Sun HJ, Chao JY, Cheng CC7,
Wu CW, Wang HW: YM500v2:
a small RNA sequencing (smRNA-seq) database for human cancer miRNome
research. Nucleic Acids Research 2015,
43(Database issue):D862-D867. PubMed
- Chen HF, Huang CH, Liu CJ, Hung JJ, Hsu CC, Teng SC, Wu KJ: Twist1
induces endothelial differentiation of tumour cells through the
Jagged1-KLF4 axis. Nat Commun 2014,
5. PubMed
- Chang LC, Lin HY, Tsai MT, Chou RH, Lee
FY, Teng CM, Hsieh MT, Hung HY, Huang LJ, Yu YL, Kuo SC:
YC-1 inhibits proliferation of breast
cancer cells by down-regulating EZH2 expression via activation of c-Cbl
and ERK. British Journal of Pharmacology 2014,
171(17):4010-4025. PubMed
- Tsai SC, Tsai MH, Chiu
CF, Lu CC, Kuo SC, Chang NW, Yang JS: AMPK-dependent
signaling modulates the suppression of invasion and migration by
fenofibrate in CAL 27 oral cancer cells through NF-κB pathway.
Environmental Toxicology 171(17):4010-4025. PubMed
- Huang HL, Kung PT, Chiu
CF, Wang
YH, Tsai WC: Factors Associated with Lung Cancer
Patients Refusing Treatment and Their Survival: A National Cohort Study
under a Universal Health Insurance in Taiwan. PLoS
ONE 2014, 9(7):e101731. PubMed
- Bai LY, Lin WY, Chiu
CF, Weng JR: Anti-tumor activities of
triterpenes from Syzygium kusukusense. Nat
Prod Commun 2014, 9(11):1557-1558.
PubMed
- Penumutchu SR, Chou
RH, Yu C: Interaction between S100P and
the anti-allergy drug cromolyn. Biochemical
and Biophysical Research Communications 2014, 454(3):404-409.
PubMed
- Tsai YP, Chen HF, Chen SY, Cheng WC, Wang
HW, Shen ZJ, Song C, Teng SC, He C, Wu KJ: TET1
regulates hypoxia-induced epithelial-mesenchymal transition by acting
as a co-activator. Genome Biology 2014,
15(12):513. PubMed