聯絡方式
電話:04-22052121 分機:7817
地址:台中市北區學士路91號
E-mail:tms@mail.cmu.edu.tw


近期發表成果
  1. Hung YL, Fang SH, Wang SC, Cheng WC, Su CC, Chen CS, Huang MY, Hua KF, Shen KH, Wang YT, Suzuki K*, Li CY: Corylin protects LPS-induced sepsis and attenuates LPS-induced inflammatory response Sci Rep. 2017. PubMed
  2. Chung IF, Chang SH, Chen CY, Liu SH, Li CY, Chan CH, Shih CC, Cheng WC: YM500v3: a database for small RNA sequencing in human cancer research. Nucleic Acids Res, Jun 2017. PubMed
  3. Wu HT, Kuo YC, Hung JJ, Huang CH, Chen WY, Chou TY, Chen Y, Chen YJ, Chen YJ, Cheng WC,Teng SC, Wu KJ.: K63-polyubiquitinated HAUSP deubiquitinates HIF-1α and dictates H3K56 acetylation promoting hypoxia-induced tumour progression. Nat Commun, 2016 Dec. PubMed
  4. Chang WC, Huang SF, Lee YM, Lai HC, Cheng BH, Cheng WC, Ho YP, Jeng LB, Ma WL.: Cholesterol import and steroidogenesis are biosignatures for gastric cancer patient survival. Oncotarget, 2016 Nov. PubMed
  5. Lai HC, Yeh CC, Jeng LB, Huang SF, Liao PY, Lei FJ, Cheng WC, Hsu CL, Cai X, Chang C, Ma WL: Androgen receptor mitigates postoperative disease progression of hepatocellular carcinoma by suppressing CD90+ populations and cell migration and by promoting anoikis in circulating tumor cells. Oncotarget 2016Jun 20. PubMed
  6. Hsu KW, Fang WL, Huang KH, Huang TT, Lee HC, Hsieh RH, Chi CW, Yeh TS: Notch1 pathway-mediated microRNA-151-5p promotes gastric cancer progression. Oncotarget 20167(25):38036-51. PubMed
  7. Huang KY, Kao SH, Wang WL, Chen CY, Hsiao TH, Salunke SB, Chen JJ, Su KY, Yang SC, Hong TM, Chen CS, Yang PC: Small Molecule T315 Promotes Casitas B-Lineage Lymphoma-Dependent Degradation of Epidermal Growth Factor Receptor via Y1045 Autophosphorylation. American Journal of Respiratory and Critical Care Medicine 2016193(7):753-66. PubMed
  8. Kao SH, Wu KJ, Lee WH: Hypoxia, Epithelial-Mesenchymal Transition, and TET-Mediated Epigenetic Changes. Journal of Clinical Medicine 20165(2), 24. PubMed
  9. Wang LK, Pan SH, Chang YL, Hung PF, Kao SH, Wang WL, Lin CW, Yang SC, Liang CH, Wu CT, Hsiao TH, Hong TM, Yang PC: MDA-9/Syntenin-Slug transcriptional complex promote epithelial-mesenchymal transition and invasion/metastasis in lung adenocarcinoma. Oncotarget 2016, 5;7(1):386-401. PubMed
  10. Chen HF, Wu KJ: Endothelial Transdifferentiation of Tumor Cells Triggered by the Twist1-Jagged1-KLF4 Axis: Relationship between Cancer Stemness and Angiogenesis. Stem Cells International 2016:6439864. PubMed
  11. Tseng SJ, Liao ZX, Kao SH, Zeng YF, Huang KY, Li HJ, Yang CL, Deng YF, Huang CF, Yang SC, Yang PC, Kempson IM: Highly specific in vivo gene delivery for p53-mediated apoptosis and genetic photodynamic therapies of tumour. Nature communications 2015, 5;6:6456. PubMed
  12. Chung IF, Chen CY, Su SC , Li CY, Wu KJ , Wang HW, Cheng WC : DriverDBv2: a database for human cancer driver gene research. Nucleic Acids Research 2015 Dec 3. pii: gkv1314. PubMed
  13. Yan FQ, Wang JQ, Tsai YP, Wu KJ: HSP60 overexpression increases the protein levels of the p110α subunit of  phosphoinositide 3-kinase and c-Myc. Clinical and Experimental Pharmacology and Physiology 2015, 42(10):1092-1097. PubMed
  14. Tseng JC, Chen HF, Wu KJ: A twist tale of cancer metastasis and tumor angiogenesis. THistology and Histopathology 2015, 30(11):1283-1294. PubMed
  15. Kuo YC, Wu HT, Hung JJ, Chou TY, Teng SC, Wu KJ: Nijmegen breakage syndrome protein 1 (NBS1) modulates hypoxia inducible factor-1α (HIF-1α) stability and promotes in vitro migration and invasion under ionizing radiation. The International Journal of Biochemistry & Cell Biology 2015, 64(0):229-238. PubMed
  16. Wang JQ, Wu KJ: Epigenetic Regulation of Epithelial-Mesenchymal Transition by Hypoxia in Cancer: Targets and Therapy. Current Pharmaceutical Design 2015, 21(10):1272-1278. PubMed
  17. Chang LC, Yu YL, Liu CY, Cheng YY, Chou RH, Hsieh MT, Lin HY, Hung HY, Huang LJ, Wu YC, Kuo SC: The newly synthesized 2-arylnaphthyridin-4-one, CSC-3436, induces apoptosis of non-small cell lung cancer cells by inhibiting tubulin dynamics and activating CDK1. Cancer Chemother Pharmacol 2015, 75(6):1303-1315. PubMed
  18. Hsieh TC, Hsieh CY, Yang TY, Chen TT, Lin CY, Lin CC, Hua CH, Chiu CF, Yeh SP, Sher YP: [18F]-Fluorodeoxyglucose Positron Emission Tomography Standardized Uptake Value as a Predictor of Adjuvant Chemotherapy Benefits in Patients With Nasopharyngeal Carcinoma. The Oncologist 2015, 20(5):539-545. PubMed
  19. Wang HW, Sun HJ, Chang TY, Lo H-H, Cheng WC, Tseng GC, Lin CT, Chang SJ, Pal NR, Chung IF: Discovering monotonic stemness marker genes from time-series stem cell microarray data. BMC Genomics 2015, 16(Suppl 2):S2-S2. PubMed
  20. Cheng WC, Chung IF, Tsai CF, Huang TS, Chen CY, Wang SC, Chang TY, Sun HJ, Chao JY, Cheng CC7, Wu CW, Wang HW: YM500v2: a small RNA sequencing (smRNA-seq) database for human cancer miRNome research. Nucleic Acids Research 2015, 43(Database issue):D862-D867. PubMed
  21. Chen HF, Huang CH, Liu CJ, Hung JJ, Hsu CC, Teng SC, Wu KJ: Twist1 induces endothelial differentiation of tumour cells through the Jagged1-KLF4 axis. Nat Commun 2014, 5. PubMed
  22. Chang LC, Lin HY, Tsai MT, Chou RH, Lee FY, Teng CM, Hsieh MT, Hung HY, Huang LJ, Yu YL, Kuo SC: YC-1 inhibits proliferation of breast cancer cells by down-regulating EZH2 expression via activation of c-Cbl and ERK. British Journal of Pharmacology 2014, 171(17):4010-4025. PubMed
  23. Tsai SC, Tsai MH, Chiu CF, Lu CC, Kuo SC, Chang NW, Yang JS: AMPK-dependent signaling modulates the suppression of invasion and migration by fenofibrate in CAL 27 oral cancer cells through NF-κB pathway. Environmental Toxicology 171(17):4010-4025. PubMed
  24. Huang HL, Kung PT, Chiu CF, Wang YH, Tsai WC: Factors Associated with Lung Cancer Patients Refusing Treatment and Their Survival: A National Cohort Study under a Universal Health Insurance in Taiwan. PLoS ONE 2014, 9(7):e101731. PubMed
  25. Bai LY, Lin WY, Chiu CF, Weng JR: Anti-tumor activities of triterpenes from Syzygium kusukusense. Nat Prod Commun 2014, 9(11):1557-1558. PubMed
  26. Penumutchu SR, Chou RH, Yu C: Interaction between S100P and the anti-allergy drug cromolyn. Biochemical and Biophysical Research Communications 2014, 454(3):404-409. PubMed
  27. Tsai YP, Chen HF, Chen SY, Cheng WC, Wang HW, Shen ZJ, Song C, Teng SC, He C, Wu KJ: TET1 regulates hypoxia-induced epithelial-mesenchymal transition by acting as a co-activator. Genome Biology 2014, 15(12):513. PubMed